Our Concept

about01

Type and characteristics of peptide, our main ingredient

Features and overview of Acetyl Hexapeptide-8

It is effective in paralyzing muscles by blocking neurotransmission as well as signal transmission from motor nerve to muscle cells.
Botox is breakdown enzyme of protein(protease), and it decomposes SNAP-25, blocking irreversibly neurotransmission. SNAP-25 is protein that is involved in secretion of synapse neurotransmitter. Accordingly, it blocks signal transmission from motor nerve to muscle cell. It is effective in paralyzing muscles and it is used to treat muscle spasm. Recently, it is used for anti wrinkle purpose.

Meanwhile, Acetyl hexapeptide is developed based on amino acid sequence that is involved in secreting neurotransmitter, such as VAMP, Snap-25, syntaxin. It imitates protein of SNAP-25 and competes with SNAP-25 that meditates biding of VAMP and STXN(syntaxin). Thus, it inhibits formation of SNARE complex, adjusting reversibly secretion of neurotransmitter. It can be used for various skin improvement items as it has little toxicity compared to Botox due to difference of reversible acting mechanism. This difference of acting mechanism is shown on <Figure-1>.

 Comparison of acting mechanism between Botox and acetyl hexapeptide-8

about02

▪ There were problems of mass production and high cost due to expensive resin when producing peptide with conventional solid phase synthesis. Because of these reasons, it has been constrains to use peptide for cosmetics in spite of excellent functionality of good biological activity.

▪ Pep101, Acetyl Hexapeptide-8, is peptide with high purity and quality. Solution Phase Synthesis method has been implemented in peptide production based on accumulated know-how of biotechnology, bioactive analysis technology, and Peptide Drug development and production know-how. Therefore, it secures mass production and stable supply.

▪ Pep101 adjusts secretion of neurotransmitter as muscle, and it prevents wrinkle, caused by repetitive muscle movement, showing anti-aging effect

Features and overview of Copper Tripeptide-1 (GHK-Cu)

▪ Copper Tripeptide-1 (GHK-Cu) is natural peptide that is derived from human body such as people’s blood, or saliva. .

▪ This peptide exists as combining form with albumin in blood. People in 20’s have about 200ng/ml of this peptide. It decreases as aging continues, reaching about 80ng/ml for people in 60’s.

▪ GHK is peptide which is decomposed and produced by protein breakdown enzyme. Upon skin damage, inflammation related protein and structural protein of intercellular substances of human body including collagen, skin collagenases, SPARC, prokininogen, and lnterleukin-4, complement C1q, are decomposed by this protein breakdown enzyme. As shown on <Figure-1>, GHK removes damaged collagen or elastin, and inhibits scar occurrence, encouraging skin regeneration through stem cell production.

 

This skin regeneration effect is known to enhance remarkably collagen production. As seen on picture below, bright part indicates significant collagen increase after using collagen to the skin on picture below.

 

As shown on picture below, when using GHK-Cu to skin wound, inflammation related cell that is involved in wound healing is significantly increased. Moreover, skin structure recovery is seen to be enhanced remarkably.

[ Pep 102 ]

▪ Pep102, Copper tripeptide-1, is peptide with high purity and quality. Solution Phase Synthesis method has been implemented in peptide production based on accumulated know-how of biotechnology, bioactive analysis technology, and peptide drug development and production know-how. Therefore, it secures mass production and stable supply.

▪ Pep102 promotes collagen production, ECM increase, and skin cell regeneration, showing anti-aging effect.

Features of Palmitoylpentateptide-4

 

PATENTS


Lifting effect (Patent No. 10-0904552)

▪ This product is very effective in restoring sagging skin to original state by lifting sagging skin with super lifting polymer (patented ingredient), developed by patented technology.


Anti-aging and whitening effect (Patent No. 0536744)

▪ This product prevents skin aging as it contains fruit extract of Oriental Raisin Tree, which is  patented ingredient for anti aging.


 

CONFERENCE

 

(Cosmetic Conference in South Asia)

(IECSC New York, 2018)

(COSMO PROF 2018, in Italy)

(Cosmetic Conference in Beijing, China, 2018)

(IECSC New York 2018)

(Cosmetic Conference in Beijing, China, 2018)